Medical ozone is a mixture of oxygen and ozone obtained from medical oxygen by using a medical device – a medical ozone generator. Ozone therapy in medicine is a growing reality, and there are more and more professionals using medical ozone as a therapeutic tool for different diseases related to chronic oxidative stress and inflammation, including chronic pain.
Particularly, ozone treatment for disc and knee problems has shown promising results in managing chronic pain and improving joint mobility without invasive surgery.
When applying this therapy, we are really inducing a controlled and harmless “micro-oxidation” that will produce a modulation of the cellular antioxidant system and the inflammation system. Ozone reacts with interstitial fluids producing hydrogen peroxide (H2O2), aldehydes, and lipid oxidation products (LOPs). These substances induce activation of the nuclear factor erythroid 2-related factor 2 (NRF2) pathway that will induce an increase in antioxidant systems (ARE), such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione s-tranferase (GSTr), hem-oxygenase-1 (HO-1), reduced nicotinamide adenine dinucleotide phosphate (NADPH), NADPH quinone oxidoreductase 1 (NQO1) and heat shock protein-70 (HSP70; Baeza et al., 2015). This NRF2 activation induces a decrease in the nuclear factor kappa beta (NFKβ) pathway activity, inducing an anti-inflammatory effect [decrease of interleukynes 1,2,6,7 and tumor necrosis factor alpha (TNFα) and increase of interlukynes 4, 10, 13 and transforming growing factor beta (TGFβ)] In the injected tissues, medical ozone inactivates proteolytic enzymes through the inhibition of the NFKβ pathway. At the same time, there is a proliferation of fibroblasts and chondrocytes, favoring cartilaginous regeneration
Ashirvad Institute for Pain Management and Research (AIPMR) is a multidisciplinary pain clinic in the heart of Mumbai. Our approach to pain is holistic, with a focus on the patient as a whole with multitargeted treatment of the pain. Our is a dedicated centre for Pain treatment with all the latest technology under one roof. We perform minimally invasive procedures for treatment of pain after we acquire an insight into patients physical and mental condition with a elaborate history taking and physical examination. Every patient with chronic pain has a long story of complaints, worries, fears and apprehensions that accompany the pain. Our approach aims to provide maximum relief from the pain, whilst trying to rehabilitate the patient, improve the functionality and let the patient attain the best Quality of life possible.
Infiltrated ozone at concentrations between 4 and 30 μg/ml is useful for treating musculoskeletal diseases such as
Among these conditions, ozone treatment for disc and knee problems has gained significant attention in the medical community. The therapy has shown remarkable effectiveness in treating degenerative disc disease and various knee conditions, offering a non-surgical alternative for patients. When administered precisely, ozone therapy can help reduce inflammation, promote tissue regeneration, and improve overall joint function in both spinal discs and knee joints.
Ashirvad Institute for Pain management and Research
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I truly thank the Ashirvad Team to take care of my mom while treating her with Love and the needling sessions. They r so so good. I will recommend the patients to visit the Ashirvad clinic without a second thought. Thank you Team Ashirvad for all your help and co ordination. Thank you very much doctor n sisters at Ashirvad Pain Relief Clinic.
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