Medical ozone is a mixture of oxygen and ozone obtained from medical oxygen by using a medical device – a medical ozone generator. Ozone therapy in medicine is a growing reality, and there are more and more professionals using medical ozone as a therapeutic tool for different diseases related to chronic oxidative stress and inflammation, including chronic pain.
Particularly, ozone treatment for disc and knee problems has shown promising results in managing chronic pain and improving joint mobility without invasive surgery.
When applying this therapy, we are really inducing a controlled and harmless “micro-oxidation” that will produce a modulation of the cellular antioxidant system and the inflammation system. Ozone reacts with interstitial fluids producing hydrogen peroxide (H2O2), aldehydes, and lipid oxidation products (LOPs). These substances induce activation of the nuclear factor erythroid 2-related factor 2 (NRF2) pathway that will induce an increase in antioxidant systems (ARE), such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione s-tranferase (GSTr), hem-oxygenase-1 (HO-1), reduced nicotinamide adenine dinucleotide phosphate (NADPH), NADPH quinone oxidoreductase 1 (NQO1) and heat shock protein-70 (HSP70; Baeza et al., 2015). This NRF2 activation induces a decrease in the nuclear factor kappa beta (NFKβ) pathway activity, inducing an anti-inflammatory effect [decrease of interleukynes 1,2,6,7 and tumor necrosis factor alpha (TNFα) and increase of interlukynes 4, 10, 13 and transforming growing factor beta (TGFβ)] In the injected tissues, medical ozone inactivates proteolytic enzymes through the inhibition of the NFKβ pathway. At the same time, there is a proliferation of fibroblasts and chondrocytes, favoring cartilaginous regeneration
One of the most notable advancements in this field is the use of ozone therapy for knee pain, which offers a minimally invasive solution for patients struggling with chronic joint discomfort. By targeting inflammation at the source and enhancing oxygen delivery to affected tissues, this therapy helps in reducing stiffness and improving mobility over time.
In clinical practice, ozone injection for knee pain is administered with precision into the affected joint, where it works to decrease inflammation, stimulate healing, and improve joint lubrication. This makes it a preferred option for individuals looking to avoid long-term medication use or surgical intervention.
Ashirvad Institute for Pain Management and Research (AIPMR) is a multidisciplinary pain clinic in the heart of Mumbai. Our approach to pain is holistic, with a focus on the patient as a whole with multitargeted treatment of the pain. Our is a dedicated centre for Pain treatment with all the latest technology under one roof. We perform minimally invasive procedures for treatment of pain after we acquire an insight into patients physical and mental condition with a elaborate history taking and physical examination. Every patient with chronic pain has a long story of complaints, worries, fears and apprehensions that accompany the pain. Our approach aims to provide maximum relief from the pain, whilst trying to rehabilitate the patient, improve the functionality and let the patient attain the best Quality of life possible.
Infiltrated ozone at concentrations between 4 and 30 μg/ml is useful for treating musculoskeletal diseases such as
Among these conditions, ozone treatment for disc and knee problems has gained significant attention in the medical community. The therapy has shown remarkable effectiveness in treating degenerative disc disease and various knee conditions, offering a non-surgical alternative for patients. When administered precisely, ozone therapy can help reduce inflammation, promote tissue regeneration, and improve overall joint function in both spinal discs and knee joints.
With growing patient demand for non-surgical solutions, ozone therapy for knee pain is increasingly being integrated into comprehensive pain management programs. It not only alleviates symptoms but also addresses the underlying causes of joint degeneration, making it a long-term therapeutic option.
Additionally, ozone injection for knee pain has shown encouraging outcomes in improving flexibility and restoring joint function, especially in patients with early to moderate osteoarthritis. When combined with rehabilitation protocols, the results can significantly enhance overall quality of life.
Living with chronic pain can impact every aspect of your life, but it doesn’t have to. At AIPMR, we specialize in advanced, minimally invasive treatments like ozone therapy that are designed to restore mobility and reduce discomfort.
Book a consultation today to explore whether ozone therapy is the right solution for your condition. Our expert team will guide you with a personalized treatment plan focused on long-term relief and improved quality of life.
Ashirvad Institute for Pain management and Research
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I truly thank the Ashirvad Team to take care of my mom while treating her with Love and the needling sessions. They r so so good. I will recommend the patients to visit the Ashirvad clinic without a second thought. Thank you Team Ashirvad for all your help and co ordination. Thank you very much doctor n sisters at Ashirvad Pain Relief Clinic.
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